Our bee-venom acanthosis nigricans cleanser contains arbutin and salicylic acid. It maintains the skin's natural barrier for increased protection. Lasting fresh, no residual burden. Its use is simple: clean your hands and wet your elbows or knees with warm water for acanthosis nigricans, acne or melanin deposits. Add a little water and rub until frothy. Apply the foam evenly with your fingertips to elbows or knees that suffer from acanthosis nigricans, acne, or melanin deposits. Rinse with water and pat the clean area with a clean towel. It also maintains the skin's natural barrier for additional protection. Lasting fresh, no residual burden.